The Guideline Definition Language (GDL) has been studied, compared and evaluated in several independent academic publications in recent years. A list of publications is available below and ranges from PhD and Master theses to scientific articles published in academic journals.

PhD and Master theses

Integration of Data with Quality Registries using Semantic EHR and CDS Technologies: A case study of the quality registry Senior Alert in Sweden. Master thesis. Karolinska Institutet; 2016

Nielsen O. “The study showed that these semantic EHR and CDS technologies can be used for the integration of data to registries, where they provide reusable and accurate data to the registry in the format and structure that it requires. The solution presented in this study shows that the quality of data can be improved […]

Comparative Analysis of HL7 FHIR and openEHR for Electronic Aggregation, Exchange and Reuse of Patient Data in Acute Care. Master thesis. Karolinska Institutet; 2016

Allwell-Brown E. “openEHR captures an outstanding level of detail and it delivers on its mandate of defining EHR structure, albeit in a tedious and complicated way. FHIR is lightweight and agile, has better terminology support, is easier to learn, maintain and rapidly deploy either as an interface for data aggregation, exchange and reuse, or as […]

Exploring openEHR-based clinical guidelines in acute stroke care and research. Thesis for doctoral degree. Karolinska Institutet; 2016

Anani N. “Several findings are that i) the Care Entry-Network Model facilitates an intermediate step between narrative guideline text and computer-interpretable guidelines to be deployed in openEHR systems, ii) the Guideline Definition Language is practicable for creating and automatically running openEHR-based computer-interpretable guidelines, where we also provide detailed accounts of our employed GDL technologies, and […]

Design and development of a decision support system for screening of Lynch syndrome using openEHR. Master thesis. Karolinska Institutet; 2015

Flores B.

Applying openEHR and GDL for streamlining the process between screening and reporting to quality registries – the case of familial hypercholesterolemia. Master thesis. Karolinska Institutet; 2014

Engblom K.

Evaluation of feasibility of openEHR and Guideline Definition Language for automatic data transfer between electronic health records and the Auricula quality registry for Atrial fibrillation. Master thesis. Karolinska Institutet; 2014

Ismaili U.

Evaluation of the Guideline Definition Language (GDL) in the clinical area of severe sepsis and septic shock. Master thesis. Karolinska Institutet; 2013

Kalliamvakos K.

Scientific Publications

Applying openEHR’s Guideline Definition Language to the SITS international stroke treatment registry: a European retrospective observational study. BMC Medical Informatics and Decision Making BMC series – open, inclusive and trusted 2017 17:7

Anani N. ; Mazya M.; Chen R.; Moreira T.; Bill O.; Ahmed N.; Wahlgren N.;Koch S.

Building Chronic Kidney Disease Clinical Practice Guidelines Using the openEHR Guideline Definition Language. Methods Inf Med. 2016 Dec 7;55(6):495-505

Lin CH, Lo YC, Hung PY, Liou DM.

Publication, Discovery and Interoperability of Clinical Decision Support Systems: a Linked Data Approach. J Biomed Inform. 2016 Aug;62:243-64.

Marco-Ruiz L. ; Pedrinaci C. ; Maldonado J.A. ; Panziera L. ; Chen R.; Gustav Bellika J. “For example, openEHR GDL uses archetypes; the Arden Syntax links directly to the database encapsulating queries in its data section; SAGE uses a VMR based on HL7 RIM [6] and [36]; and recent developments such as the EU project Mobiguide [37] advocate for […]

A semantic web based framework for the interoperability and exploitation of clinical models and EHR data. Knowledge-Based Systems, 1 August 2016, Vol.105, pp.175-189

Legaz-García, María Del Carmen ; Martínez-Costa, Catalina ; Menárguez-Tortosa, Marcos ; Fernández-Breis, Jesualdo Tomás.

Personalization and Patient Involvement in Decision Support Systems: Current Trends. IMIA Yearbook, 2015, pp.106-118.

Quaglini S. ; Sacchi L. ; Lanzola G. ; Viani R. Röhrig D N. O´Sullivan ; S. Wilk ; W. Michalowski ; R. Slowinski ; R. Thomas ; M. Kadzinski ; K. Farion A. Geissbuhler. “This highlights the current trend to replace specialized environments by inference engines built on top of standardized frameworks that allow […]

Computerized Clinical Decision Support: Contributions from 2014. Managing Editor for the Imia Yearbook Section on Sensors ; Signals ; and Imaging Informatics P. Ruch ; Managing Editor for the Imia Yearbook Section on Human Factors D. Kubias. IMIA Yearbook, 2015, pp.119-124.

Bouaud J.;Koutkias V. Müller H. “To summarize recent research and propose a selection of best papers published in 2014 in the field of computerized clinical decision support for the Decision Support section of the IMIA yearbook. Anani et al. [21] worked on the assessment of compliance with practice guidelines for acute stroke care. The study […]

Retrospective checking of compliance with practice guidelines for acute stroke care: a novel experiment using openEHR’s Guideline Definition Language. BMC Med Inform Decis Mak. 2014 May 10;14:39. doi: 10.1186/1472-6947-14-39

Anani N, Chen R, Prazeres Moreira T, Koch S.

Early Experiences from a guideline-based computerized clinical decision support for stroke prevention in atrial fibrillation. Stud Health Technol Inform. 2013;192:244-7.

Chen R, Valladares C, Corbal I, Anani N, Koch S. “The compliance checking shows the cardiologist group has substantially higher percentage of compliant treatment compared with that of the general population group. Based on this important finding, we are now implementing at-point-of-care clinical decision support reusing the same computerized guideline knowledge in GDL format in order to […]

OpenEHR-based representation of guideline compliance data through the example of stroke clinical practice guidelines. Studies in Health Technology and Informatics. 2012;180:487-491.

Anani N, Chen R, Prazeres Moreira T, Koch S. “We conclude that openEHR-based guideline and compliance data representations may be a promising first step in building future decision support applications that are well connected to the electronic health record, can be useful in locating discrepancies between different sets of guidelines within the same care context […]